解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Despite quick implementation of reperfusion therapies, a few patients with high-risk, acute, massive, pulmonary embolism (PE) remain highly hemodynamically unstable. Others have absolute contraindication to receive reperfusion therapies. Venoarterial-extracorporeal membrane oxygenation (VA-ECMO) might lower ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-017-1655-8
更新日期:2017-03-28 00:00:00
abstract::This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2017. Other selected articles can be found online at http://ccforum.com/series/annualupdate2017 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-017-1642-0
更新日期:2017-03-21 00:00:00
abstract::This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2017. Other selected articles can be found online at http://ccforum.com/series/annualupdate2017 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-017-1639-8
更新日期:2017-03-21 00:00:00
abstract:BACKGROUND:Acute respiratory failure (ARF) remains a common hazardous complication in immunocompromised patients and is associated with increased mortality rates when endotracheal intubation is needed. We aimed to evaluate the effect of early noninvasive ventilation (NIV) compared with oxygen therapy alone in this pati...
journal_title:Critical care (London, England)
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s13054-016-1586-9
更新日期:2017-01-07 00:00:00
abstract:BACKGROUND:Patients with infective endocarditis (IE) have an elevated risk of renal dysfunction because of extensive systemic inflammation and use of nephrotoxic antibiotics. In this randomized, placebo-controlled trial, we investigated whether perioperative sodium bicarbonate administration could attenuate postoperati...
journal_title:Critical care (London, England)
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13054-016-1591-z
更新日期:2017-01-05 00:00:00
abstract:BACKGROUND:Epidemiological studies have provided inconsistent results on whether intensive care unit (ICU) discharge at night and on weekends is associated with an increased risk of mortality. This systematic review and meta-analysis aimed to determine whether ICU discharge time was associated with hospital mortality. ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s13054-016-1569-x
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Inhaled nitric oxide (iNO) is a rescue therapy for severe hypoxemia in patients with acute respiratory distress syndrome (ARDS). Pooled data from clinical trials have signaled a renal safety warning for iNO therapy, but the significance of these findings in daily clinical practice is unclear. We used primary...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1566-0
更新日期:2016-11-30 00:00:00
abstract:BACKGROUND:Acute kidney injury (AKI) is common among intensive care unit (ICU) patients. AKI is highly heterogeneous, with variable links to poor outcomes. Current approaches to classify AKI severity and identify patients at highest risk for poor outcomes focus on the maximum change in serum creatinine (SCr) values. Ho...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/s13054-016-1546-4
更新日期:2016-11-17 00:00:00
abstract:BACKGROUND:The lack of a patent source of infection after 24 hours of management of shock considered septic is a common and disturbing scenario. We aimed to determine the prevalence and the causes of shock with no diagnosis 24 hours after its onset, and to compare the outcomes of patients with early-confirmed septic sh...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/s13054-016-1537-5
更新日期:2016-11-06 00:00:00
abstract:BACKGROUND:The present study was designed to (1) establish current sedation practice in UK critical care to inform evidence synthesis and potential future primary research and (2) to compare practice reported via a survey with actual practice assessed in a point prevalence study (PPS). METHODS:UK adult general critica...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1532-x
更新日期:2016-10-27 00:00:00
abstract:BACKGROUND:There is growing interest in patient outcomes following critical illness, with an increasing number and different types of studies conducted, and a need for synthesis of existing findings to help inform the field. For this purpose we conducted a systematic review of qualitative studies evaluating patient out...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-016-1516-x
更新日期:2016-10-26 00:00:00
abstract:BACKGROUND:Acute kidney injury and hyperchloremia are commonly present in critically ill septic patients. Our study goal was to evaluate the association of hyperchloremia and acute kidney injury in severe sepsis and septic shock patients. METHODS:In this retrospective cohort study in a provincial tertiary care hospita...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1499-7
更新日期:2016-10-06 00:00:00
abstract:BACKGROUND:Impaired microcirculatory perfusion and tissue oxygenation during critical illness are associated with adverse outcome. The aim of this study was to detect alterations in tissue oxygenation or microvascular reactivity and their ability to predict outcome in critically ill patients using thenar near-infrared ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1500-5
更新日期:2016-10-01 00:00:00
abstract::Mechanically ventilated, intubated patients are at increased risk for tracheal colonization with bacterial pathogens that may progress to heavy bacterial colonization, ventilator-associated tracheobronchitis (VAT), and/or ventilator-associated pneumonia (VAP). Previous studies report that 10 to 30 % of patients with V...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1472-5
更新日期:2016-09-29 00:00:00
abstract:BACKGROUND:Atrial fibrillation occurs frequently in patients following cardiac surgery and can be a cause of increased morbidity and mortality. The use of dexmedetomidine to prevent atrial fibrillation is unclear. The present study was designed to evaluate the effect of dexmedetomidine sedation on the incidence of atri...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1480-5
更新日期:2016-09-21 00:00:00
abstract::Many aspects of left ventricular function are explained by considering ventricular pressure-volume characteristics. Contractility is best measured by the slope, Emax, of the end-systolic pressure-volume relationship. Ventricular systole is usefully characterized by a time-varying elastance (ΔP/ΔV). An extended area, t...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-016-1439-6
更新日期:2016-09-10 00:00:00
abstract:BACKGROUND:In order to improve assessment and outcome prediction in patients suffering from traumatic brain injury (TBI), cerebral protein levels in serum have been suggested as biomarkers of injury. However, despite much investigation, biomarkers have yet to reach broad clinical utility in TBI. This study is a 9-year ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1450-y
更新日期:2016-09-08 00:00:00
abstract:BACKGROUND:Expert systems can help alleviate problems related to the shortage of human resources in critical care, offering expert advice in complex situations. Expert systems use contextual information to provide advice to staff. In mechanical ventilation, it is crucial for an expert system to be able to determine the...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1436-9
更新日期:2016-08-14 00:00:00
abstract:BACKGROUND:Critical illness myopathy is an acquired skeletal muscle disorder with severe myosin loss and muscle weakness frequently seen in intensive care unit (ICU) patients. It is unknown if impaired excitation-contraction coupling contributes to the muscle weakness. METHODS:We used a unique ICU model where rats wer...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1417-z
更新日期:2016-08-10 00:00:00
abstract::Prior to 2001 there was no standard for early management of severe sepsis and septic shock in the emergency department. In the presence of standard or usual care, the prevailing mortality was over 40-50 %. In response, a systems-based approach, similar to that in acute myocardial infarction, stroke and trauma, called ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-016-1288-3
更新日期:2016-07-01 00:00:00
abstract::Venovenous extracorporeal membrane oxygenation (vv-ECMO) has been classically employed as a rescue therapy for patients with respiratory failure not treatable with conventional mechanical ventilation alone. In recent years, however, the timing of ECMO initiation has been readdressed and ECMO is often started earlier i...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-016-1329-y
更新日期:2016-06-30 00:00:00
abstract:BACKGROUND:Chemokine (C-X3-C motif) receptor 1 (CX3CR1) was identified as the most differentially expressed gene between survivors and non-survivors in two independent cohorts of septic shock patients and was proposed as a marker of sepsis-induced immunosuppression. Whether such a biomarker is associated with mortality...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1362-x
更新日期:2016-06-30 00:00:00
abstract::Hypotension during intermittent hemodialysis is common, and has been attributed to acute volume shifts, shifts in osmolarity, electrolyte imbalance, temperature changes, altered vasoregulation, and sheer hypovolemia. Although hypovolemia may intuitively seem a likely cause for hypotension in intensive care patients, i...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1307-4
更新日期:2016-06-09 00:00:00
abstract:BACKGROUND:Early survival following severe injury has been improved with refined resuscitation strategies. Multiple organ dysfunction syndrome (MODS) is common among this fragile group of patients leading to prolonged hospital stay and late mortality. MODS after trauma is widely attributed to dysregulated inflammation ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1341-2
更新日期:2016-06-07 00:00:00
abstract:BACKGROUND:Oliguria is one of the leading triggers of fluid loading in patients in the intensive care unit (ICU). The purpose of this study was to assess the predictive value of urine Na(+) (uNa(+)) and other routine urine biomarkers for cardiac fluid responsiveness in oliguric ICU patients. METHODS:We conducted a pro...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/s13054-016-1343-0
更新日期:2016-05-29 00:00:00
abstract::Severe critical illness is often complicated by intensive care unit-acquired weakness (ICU-AW), which is associated with increased ICU and post-ICU mortality, delayed weaning from mechanical ventilation and long-term functional disability. Several mechanisms have been implicated in the pathophysiology of ICU-AW, but m...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1308-3
更新日期:2016-05-19 00:00:00
abstract:BACKGROUND:Post-cardiac arrest (CA) patients are at risk of secondary ischemic damage in the case of suboptimal brain oxygenation during an ICU stay. We hypothesized that elevated central venous pressures (CVP) would impair cerebral perfusion and oxygenation (venous cerebral congestion). The aim of the present study wa...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1297-2
更新日期:2016-05-15 00:00:00
abstract:BACKGROUND:Middle East respiratory syndrome coronavirus infection is associated with high mortality rates but limited clinical data have been reported. We describe the clinical features and outcomes of patients admitted to an intensive care unit (ICU) with Middle East respiratory syndrome coronavirus (MERS-CoV) infecti...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1303-8
更新日期:2016-05-07 00:00:00
abstract:BACKGROUND:Coagulation can be visualised using whole blood coagulation analyses such as thromboelastometry and platelet aggregation tests; however, the role of temperature in the analyses is ambiguous. The aim was to examine whether temperature influences the whole blood coagulation tests. METHODS:We included 40 patie...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1302-9
更新日期:2016-04-30 00:00:00
abstract:BACKGROUND:Esophageal pressure (Pes) can provide information to guide mechanical ventilation in acute respiratory failure. However, both relative changes and absolute values of Pes can be affected by inappropriate filling of the esophageal balloon and by the elastance of the esophagus wall. We evaluated the feasibility...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1278-5
更新日期:2016-04-11 00:00:00
abstract:BACKGROUND:The purpose of this study was to determine whether the provision of corticosteroids improves time to shock reversal and outcomes in patients with post-cardiac arrest shock. METHODS:We conducted a randomized, double-blind trial of post-cardiac arrest patients in shock, defined as vasopressor support for a mi...
journal_title:Critical care (London, England)
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13054-016-1257-x
更新日期:2016-04-03 00:00:00
abstract:BACKGROUND:The purpose of this study was to examine hospital mortality, long-term mortality, and health service utilization among critically ill patients. We also determined whether these outcomes differed according to demographic and clinical characteristics. METHODS:We conducted a retrospective cohort study of adult...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1248-y
更新日期:2016-03-31 00:00:00
abstract::This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2016. Other selected articles can be found online at http://www.biomedcentral.com/collections/annualupdate2016. Further information about the Annual Update in Intensive Care and Emergency Medicine is available f...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-016-1234-4
更新日期:2016-03-16 00:00:00
abstract:BACKGROUND:In critical care units, pupil examination is an important clinical parameter for patient monitoring. Current practice is to use a penlight to observe the pupillary light reflex. The result seems to be a subjective measurement, with low precision and reproducibility. Several quantitative pupillometer devices ...
journal_title:Critical care (London, England)
pub_type: 临床试验,杂志文章
doi:10.1186/s13054-016-1239-z
更新日期:2016-03-13 00:00:00
abstract:BACKGROUND:The safety of perioperative hyperoxia is currently unclear. Previous studies in patients undergoing coronary artery bypass surgery suggest reduced myocardial damage when avoiding extreme perioperative hyperoxia (>400 mmHg). In this study we investigated whether an oxygenation strategy from moderate hyperoxia...
journal_title:Critical care (London, England)
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13054-016-1240-6
更新日期:2016-03-10 00:00:00
abstract:BACKGROUND:In hospitalised patients, anaemia increases the risk of developing acute kidney injury (AKI). Our aim was to determine whether anaemia also has an impact on the risk of progression from early AKI to more severe AKI in critically ill patients. METHODS:We retrospectively analysed the data of patients admitted...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1231-7
更新日期:2016-03-08 00:00:00
abstract:BACKGROUND:There are no easily available markers of renal recovery to guide intermittent hemodialysis (IHD) weaning. The aim of this study was to identify markers for IHD weaning in critically ill patients with acute kidney injury (AKI). METHODS:We performed a retrospective single-center cohort study of patients treat...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1225-5
更新日期:2016-02-19 00:00:00
abstract:BACKGROUND:Electrical impedance tomography (EIT) is a non-invasive bedside tool which allows an individualized ventilator strategy by monitoring tidal ventilation and lung aeration. EIT can be performed at different cranio-caudal thoracic levels, but data are missing about the optimal belt position. The main goal of th...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-015-1161-9
更新日期:2016-01-08 00:00:00
abstract:BACKGROUND:Critical illness following head injury is associated with a hypermetabolic state but there are insufficient epidemiological data describing acute nutrition delivery to this group of patients. Furthermore, there is little information describing relationships between nutrition and clinical outcomes in this pop...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-015-1177-1
更新日期:2016-01-07 00:00:00
abstract:INTRODUCTION:Fractalkine is a chemokine implicated as a mediator in a variety of inflammatory conditions. Knowledge of fractalkine release in patients presenting with infection to the Intensive Care Unit (ICU) is highly limited. The primary objective of this study was to establish whether plasma fractalkine levels are ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-015-1125-0
更新日期:2015-11-25 00:00:00